Ten friends get in the illegal drugs business, thinking it is the fastest way to become rich, but it is not going to have a happy ending because in this business, everything vanishes in the end.
The illegal drugs traffic world seems to be really attractive for fifteen years-old Martín Gonzales played by Manolo Cardona, an ambitious and bold young man, coming from a middle-class Colombian family. Martín asks his friend, Pepe Cadena played by Diego Cadavid, to talk to his brother to get him a job in the dangerous business.
Ignoring this choosing is just the beginning of a turbulent and troubled life that is going to change his fate forever, Martín alias "Fresita" gets a job in a drugs lab sponsored by the big boss Óscar Cadena (Fernando Solorzano). Martín learns really fast and he starts to send illegal drugs to the United States, while his boss makes an alliance with the Villegas Brothers, from the West Cartel, to take down the biggest drug dealer ever: Pablo Escobar.
With Escobar down, a new cartel is up: The Pacific Cartel, the most dangerous in Colombia, led by Óscar Cadena, so Óscar (the teacher) and Martín (the student) make a pact of friendship and business.
Martín becomes a rich man and he falls for Sofía (Karen Martinez), a beautiful woman, but he gets her heart by lying to her. But Sofía discovers the origin of Martín's wealth and he has to choose: Sofía or the business.
Óscar helps the police to finish the West Cartel. The snitches (sapos) make the war between these criminal machineries to reach a point of breaking.
Martín refuses to take part in this war and decides to go to Miami with Sofía and his children, but what he does not know is that it is not a safe place anymore, and he must keep going with the old illegal activities, watching his old friends die by the enemy.
Business partners and brothers dead or caught, forces Martín to run to Mexico looking for protection. He realizes too late that in this business; you can never win...